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Details
Factory sells 4-CHLORO-4'-METHOXYBUTYROPHENONE 40877-19-8 with sufficient production capacity
- Molecular Formula: C11H13ClO2
- Molecular Weight: 212.676
- Appearance/Colour: off-white to grey or brownish crystalline powder
- Melting Point: 32-35 °C(lit.)
- Refractive Index: 1.4580 (estimate)
- Boiling Point: 159-163°C 2mm，343.9 °C at 760 mmHg
- Flash Point: 145.5 °C
- PSA： 26.30000
- Density: 1.123 g/cm3
- LogP: 2.89690
40877-19-8 Relevant articles
A Facile Total Synthesis of Mubritinib
Wang, Rong,Cui, Menghan,Yang, Qing,Kuang, Chunxiang
supporting information, p. 978 - 982 (2021/02/03)
A five-step, practical, and concise tota...
Synthesis of Pyrrolidines by a Csp3-Csp3/Csp3-N Transition-Metal-Free Domino Reaction of Boronic Acids with γ-Azido-N-Tosylhydrazones
Florentino, Lucía,López, Lucía,Barroso, Raquel,Cabal, María-Paz,Valdés, Carlos
supporting information, p. 1273 - 1280 (2020/12/01)
The reaction between γ-azido-N-tosylhydr...
Synthesis method of mubritinib triazole intermediate
-
Paragraph 0028-0033; 0048-0119, (2020/12/06)
The invention discloses a method for syn...
The synthesis of ω-(2-aryl-1,3-dioxolan-2-yl)alkyl purine derivatives and their activity towards HIV reverse transcriptase
Komissarov,Valuev-Elliston,Ivanova,Kochetkov,Kritzyn
, p. 37 - 45 (2015/02/05)
Novel derivatives of 6-substituted purin...
40877-19-8 Process route
-
-
100-66-3
methoxybenzene
-
-
4635-59-0
4-Chlorobutanoyl chloride
-
-
40877-19-8
4-chloro-1-(4-methoxyphenyl)butan-1-one
| Conditions | Yield |
|---|---|
|
With
aluminum (III) chloride;
In
dichloromethane;
at 0 - 15 ℃;
for 1h;
Solvent;
|
99%
|
|
With
aluminum (III) chloride;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
|
99%
|
|
methoxybenzene;
With
aluminum (III) chloride;
In
toluene;
at -10 ℃;
for 0.25h;
4-Chlorobutanoyl chloride;
In
toluene;
at -10 ℃;
for 0.75h;
|
97%
|
|
aluminium trichloride;
In
carbon disulfide;
at 40 - 50 ℃;
for 0.5h;
Product distribution;
reactions with var. aromatic compounds;
|
95%
|
|
aluminium trichloride;
In
carbon disulfide;
at 40 - 50 ℃;
for 0.5h;
|
95%
|
|
With
aluminum (III) chloride;
In
dichloromethane;
at 5 - 15 ℃;
for 2h;
|
90%
|
|
4-Chlorobutanoyl chloride;
With
aluminum (III) chloride;
In
1,2-dichloro-ethane;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
methoxybenzene;
In
1,2-dichloro-ethane;
at -15 ℃;
for 1h;
Inert atmosphere;
|
89%
|
|
With
aluminium trichloride;
In
carbon disulfide;
at 20 ℃;
for 2h;
|
56.4%
|
|
With
aluminium trichloride;
In
1,2-dichloro-ethane;
for 0.5h;
Ambient temperature;
|
|
|
|
|
|
With
aluminium trichloride;
|
|
|
With
aluminum (III) chloride;
In
dichloromethane;
at 0 - 20 ℃;
|
|
|
With
aluminum (III) chloride;
In
dichloromethane;
at 0 - 25 ℃;
for 3h;
Inert atmosphere;
|
|
|
With
aluminum (III) chloride;
at 0 - 20 ℃;
for 2.08333h;
|
-
-
33397-21-6
tris(4-methoxyphenyl)bismuth
-
-
4635-59-0
4-Chlorobutanoyl chloride
-
-
40877-19-8
4-chloro-1-(4-methoxyphenyl)butan-1-one
| Conditions | Yield |
|---|---|
|
With
triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane;
at 80 ℃;
for 3h;
|
66%
|
40877-19-8 Upstream products
-
104-92-7
1-bromo-4-methoxy-benzene
-
628-20-6
4-Chlorobutyronitrile
-
100-66-3
methoxybenzene
-
4635-59-0
4-Chlorobutanoyl chloride
40877-19-8 Downstream products
-
112933-71-8
α-(4-methoxy-phenyl)-α-(methylsulfinyl)methyl-cyclopropanemethanol
-
75343-39-4
3-(4-Methoxy-phenyl)-1-phenyl-1,4,5,6-tetrahydro-pyridazine
-
80087-39-4
1-Methyl-5-[3-(4-methoxybenzoyl)propyl]thio-1,2,3,4-tetrazole
-
130570-14-8
3-p-Methylphenyl-3-hydroxy-N-(4'-p-methoxyphenyl-4'-oxobutyl)quinuclidinium Chloride
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